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Functions of the main constituents:
N-acetylcysteine (NAC) is a molecule derived from the natural amino acid cysteine.
NAC is one of the most powerful antioxidants known. The antioxidant property derives:
- From the presence in its chemical structure of a thiol group that can directly scavenge free radicals
- from its ability to regenerate glutathione, another very powerful antioxidant produced by our body
- by its ability, within cells, to be deacetylated into cysteine.
Cysteine, in turn, is metabolized into a series of compounds (3-mercapto-pyruvate and reduced sulfur) with antioxidant properties.
In addition to its antioxidant properties, NAC acts as an anti-inflammatory by blocking the activation of NF-kB, a transcription factor that induces the expression of genes coding for proinflammatory cytokines.
In addition, NAC, by facilitating nitric oxide production, plays an important role in vasodilation.
Several studies in the literature have shown the efficacy of NAC supplementation in various conditions:
- it is a potent mucolytic
- protects retinal cells from excessive oxidative damage in macular degeneration
- improves several skin diseases
- is able to counteract neurodegenerative and mental health diseases
Glutathione is a molecule widely represented in our body. Structurally, it consists of three amino acids cysteine, glycine and glutamic acid. It manifests important antioxidant activities to protect us from the action of free radicals, detoxifying and immuno-modulatory activities. Glutathione is useful in mild to moderate hepato-biliary insufficiency, liver intoxication due to drug use, alcohol abuse, heavy metal intoxication, and to prevent skin aging prolonged exposure to sunlight. Within red blood cells, it prevents the oxidation of hemoglobin into methemoglobin, a molecule that is unable to transport oxygen. The consequences of glutathione deficiency are related to increased oxidative stress and can manifest either as immune system disorders (disease) or as enzyme malfunction ultimately promoting damage to cellular structures, an accelerated aging process, and aggravation of existing diseases.
Like a large amount of active ingredients, glutathione also has unfavorable pharmacokinetics: after oral administration, in fact, glutathione undergoes a series of changes in the gastrointestinal tract that prevent its assimilation.
This means that, over time, the trend in the concentration of this molecule in different body fluids and tissues is short. Moreover, to make matters worse, reduced glutathione tends to arrive already oxidized (hence inactive) at the cellular target. Therefore, the percentage that generally reaches the liver cell particularly low.
To overcome these availability problems and make the product effective, the glutathione used in GluNAC, is a liposomal glutathione. LipoCellTech™ uses the most advanced production method of liposomal powder products. This production method has its origin in nature. No heat, high pressure or chemicals are used during the production process. This means that liposomal products are 100 percent natural and are almost completely absorbed by the body.
Liposomes are molecules with an outer shell consisting of healthy lipids. The liposomal globule is absorbed into the bloodstream from the small intestine, with the active substance remaining completely intact.
The outer layer of the liposome protects the contents of the liposome from gastric juices, liver enzymes and the intestines. Thanks to the natural lipids, they are protected during their journey through the stomach and intestinal tract.
Chains and fatty acid molecules such as phosphadithylcholine are used as the delivery mechanism in liposomes. As soon as a liposome finishes delivering ingredients, the liposome itself becomes a nutrient and building material for the brain, liver, and cells. This happens because the composition of the liposome is identical to the material in the body. To be precise, it is identical to the composition of the cell wall. This allows liposomes to fuse into human cells in their entirety.
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